Breast Cancer Treatment Choices
Breast cancer can be treated with a mastectomy or breast preservation surgery, lumpectomy, followed by radiation and sometimes chemotherapy. These are the best ways to prevent recurrence of cancer. The most common place for cancer to come back is in the same area where it was found the first time.
The determination of which treatment is best for an individual is based on the pathology of the disease. The initial biopsy, which is done when the cancer is first suspected, will tell what type of cancer is present and whether it is hormone receptive. The knowledge of hormone receptors, or not, found will be part of the decision making information for an individual’s treatment. Some types of tumors are stimulated by normal hormones found in a woman’s body, such as progesterone, estrogen, and HER-2. A tumor may show a positive response to one or more of these hormones. By knowing this information, a plan of treatment can be offered that will improve a woman’s chances of cancer free survival.
The pathology from the surgery, done to remove the cancer tumor, will tell if the entire tumor was removed and if cancer was found in the lymph nodes. During surgery the surgeon can see the cancer tumor, but not all of the cancer cells can be visualized. So the tumor is sent to a pathologist who puts the tumor and the surrounding tissue that was removed by the surgeon under a microscope. This way cancer cells that might be outside the main tumor can be seen. The lymph nodes that were removed in surgery can also be looked at under a microscope and it can be determined if there are cancer cells found in the lymph nodes. Often a Sentinel Node can be found, if a dye is used before surgery. This dye is injected before surgery and will show which node is the main node that drains fluid from the cancer tumor site. (The lymphatic system drains non blood fluids throughout the body.)
If lymph nodes are found to have cancer cells within them the cancer has moved from the tumor site to other areas in the body. This movement of cancer cells away from the tumor indicates metastasis, or stray cancer cells that are traveling in the body. The final pathology will offer much information about the type of cancer, the location of the cancer and how best to treat the cancer to provide a cancer free life for the woman.
A woman who has been diagnosed with cancer, from a biopsy, then will see a surgeon who specializes in breast cancer. Surgery to remove the tumor is always needed, as long as the tumor is in the breast it will grow and chances are the cancer cells will travel away from the main tumor and spread throughout the body. These cells that move away from the main tumor will settle and grow into tumors in other parts of the body, not just the breast. The surgeon will ask questions about the woman’s health and ask about the woman’s family. If a woman has family members that have, or have had breast cancer, this information will be included in treatment decisions. The surgeon then will discuss ways to treat the cancer. A mastectomy which is a removal of the breast that has the cancer in it, with one or more lymph nodes removed is one choice. A lumpectomy which is removal of the cancer tumor and a small amount of tissue surrounding the tumor is another choice. The size of the tumor, determined by the mammogram, will influence these choices. If the tumor is large a lumpectomy may not be a good choice. The smaller the tumor, the better the chances of survival for the woman. The larger the tumor the more involved the surgery will need to be, such as a mastecomy. Sometimes chemotherapy is needed before surgery; the chemotherapy will hopefully shrink the tumor and kill cancer cells that may have moved away from the main tumor (metastasized). When this is done before the surgery, the hope is that after surgery most or all of the cancer will be gone and only radiation will be needed. Chemotherapy may be needed after surgery depending on the type and stage of the cancer.
Often the surgeon will ask a woman to see a radiation oncologist before her surgery. This consultation will allow the radiation oncologist, another cancer doctor who specializes in radiation, to review the woman’s case and to offer choices of treatment. The options this doctor may offer are whole breast radiation after surgery, or partial breast radiation after surgery, or no radiation if a woman has a mastectomy and no cancer cells are found outside the breast that was removed in surgery.
One type of partial breast radiation is brachytherapy. Breast brachytherapy has been available for some time, but not all doctors are familiar with it. Brachytherapy of the breast is a good choice for some women. The size of the tumor and the location of the tumor are two of the determinations if this is a good choice. If the cancer is found out side of the breast, brachytherapy is not a choice for a woman. Brachytherapy is radiation given to the area where the cancer tumor was. This is where most cancers come back, in the same area they were to begin with. Brachytherapy can be given over five days, where as whole breast radiation if given over 6 weeks. This is an advantage for women who do not live near a cancer treatment center, women who live busy lives (most women do), or women who don’t want to prolong their treatments. When a woman chooses breast brachytherapy the applicator that will allow radiation to go right into the space where the cancer was; is placed at the time of surgery. Brachy means close. It is another advantage of brachytherapy. Only the tissue around where the cancer tumor was is radiated; the normal tissue is exposed either not at all or to such a low level of radiation it is not affected by the radiation.
The brachytherapy treatments are given two times a day, at least 6 hours between treatments, for a total of ten treatments. This type of radiation requires special equipment and knowledge, many cancer centers now have both the equipment and the radiation oncologists that are specialized in this treatment.
The other type of partial breast radiation is accelerated partial breast radiation. This type of treatment also requires that the tumor is small and no cancer has been found outside the breast. This type of radiation can be given over a shortened time, days instead of weeks. The equipment to give these treatments is IMRT, which most if not all cancer centers have. This is external beam radiation that goes from the outside of the breast to the inside of the breast and radiates all of the tissue in the area. The advantages to this treatment are it takes less time, although it is also two treatments a day at least 6 hours apart, and it only radiates the portion of the breast where the cancer tumor was.
Whole breast radiation has been around for a very long time and is what all women received until the past 15 years or so. This type of radiation involves one treatment a day Monday through Friday for 6 weeks, a total of 30 treatments. It is external beam radiation that goes from the outside of the breast to the inside of the breast and radiates all of the tissue in the breast and surrounding area, not just the area where the tumor was. This type of treatment is favored when the tumor is larger or the cancer cells were found outside of the breast, such as in one or more lymph nodes. The lymph nodes can be included in the whole breast radiation. Some women will choose whole breast radiation because it has been used for so very long. Partial breast radiation has shown the same effectiveness in studies, when the woman is a candidate for brachytherapy.
Chemotherapy and biological therapy or hormone therapies are needed in specific cases. These treatment choices should be discussed with the surgeon, the radiation oncologist and a medical oncologist.
What ever choose a woman is given they need to be well understood before she makes her decision. Asking questions of her doctors and talking to her loved ones will be helpful. If a woman’s decision is thought out it will probably be the best choice for her. Prayer always is beneficial.